What are health benefits of K2?
K2 for Bone Health
Bone mass or density is lost as people age, especially in women after menopause. The bones lose calcium and other minerals.
Several studies indicate that vitamin K2 as MK-7 may have a main role in bone tissue homoeostasis at already 45 µg/daily improving bone mineral density (BMD) and playing a critical role in the activation of bone formation by osteoblasts cells, and in the suppression of bone resorption. Other studies have shown that vitamin K2 inhibits the synthesis of prostaglandin E2 (PGE-2) which acts as a potent stimulator of bone resorption involved in the regulation and turnover of bone.
Co-incubation of vitaMK7® with TNFα, a pro-inflammatory cytokine that induces PGE2 release has been evaluated in in vitro study. vitaMK7® is effective in inhibits the PGE-2 production to levels comparable to baseline values.
K2 for Heart Health
Several studies highlight the need for good levels of vitamin K2 as MK-7 in supporting cardiovascular health and in preventing the development of Cardio Vascular Disease (CVD). Inverse relationship was demonstrated between dietary intake of Menaquinone and aortic calcification myocardial infarction and sudden cardiovascular death.
In a cross-sectional study among 564 healthy Dutch postmenopausal women participating in the Predictors of Response to Cardiac Resynchronization Therapy Study (PROSPECT) study, of which 62% with calcification, higher dietary intake of vitamin K2 (but not vitamin K1) was associated with a reduced risk of coronary calcification.