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Several studies highlight the need for good levels of vitamin K2 as MK-7 in supporting cardiovascular health and in preventing the development of Cardio Vascular Disease (CVD).

Inverse relationship was demonstrated between dietary intake of Menaquinone and aortic calcification myocardial infarction and sudden cardiovascular death.

The Rotterdam Study in 2004 evaluated the relationship between dietary intake of vitamin K and aortic calcification, heart disease and all-cause mortality. The population-based study took place over a 10-year period, included 4,807 men and women 55 years of age or older at the start. The result supports a protective effect of dietary Menaquinone intake against CHD in older men and women.

Geleijnse JM, Vermeer C, Grobbee DE, et al. Dietary intake of Menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. J Nutr. 2004

In a cross-sectional study among 564 healthy Dutch postmenopausal women participating in the Predictors of Response to Cardiac Resynchronization Therapy Study (PROSPECT) study, of which 62% with calcification, higher dietary intake of vitamin K2 (but not vitamin K1) was associated with a reduced risk of coronary calcification.

Beulens JW, Bots ML, Atsma F, Bartelink ML, Prokop M, Geleijnse JM, Witteman JC, Grobbee DE, van der Schouw YT. High dietary menaquinone intake is associated with reduced coronary calcification. Atherosclerosis 2009

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