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Bone mass or density is lost as people age, especially in women after menopause.
The bones lose calcium and other minerals.
Optimum calcium level is required for healthy life effecting cell function, bone structure and calcium homeostasis depends on the interplay of modulator compounds of which vitamin K2, especially Menaquinone-7, has assumed a vital and key role in the last decades.
Several studies indicate that Vitamin K2 as MK-7 may have a main role in bone tissue homeostasis at already 45 µg/daily improving bone mineral density (BMD) and playing a critical role in the activation of bone formation by osteoblastic cells, and in the suppression of bone resorption. Other studies have shown that vitamin K2 inhibits the synthesis of prostaglandin E2 (PGE-2) which acts as a potent stimulator of bone resorption involved in the regulation and turnover of bone.
Co-incubation of vitaMK7® with TNFα, a pro-inflammatory cytokine that induces PGE2 release has been evaluated in in-vitro study.
VitaMK7® is effective in inhibits the PGE-2 production to levels comparable to baseline values.
A groundbreaking study by Kaneki in 2001 suggested that increased intake of natural vitamin K2 as MK-7 from natto food resulted in better levels of undercarboxylated osteocalcin (c-OC) and a reduced risk of hip fracture. The INCREASE of plasma levels of c-OC and OC in healthy volunteers has been evaluated after vitaMK7® supplementation for 3 weeks.